Publications

2024

Noorani A, Tavallaee G, Orouji E. Benchmarking peak calling methods for CUT&RUN. BioRxiv. 2024.  More

Ouladan S, Orouji E. Beyond traditional subtyping: a multilayered genomic perspective on colorectal cancer. 

Gut. 2024.  More

2023

McKeever PM, ... Orouji E, ... , Robertson J. Single-nucleus multiomic atlas of frontal cortex in amyotrophic lateral sclerosis with a deep learning-based decoding of alternative polyadenylation mechanisms. BioRxiv. 2023.  More

Wei Z, ... Orouji E, ... , Guo H. MYC reshapes CTCF-mediated chromatin architecture in prostate cancer. Nat Commun. 2023.  More

Creighton SD, ... Orouji E, Zovkic I. Sex‐specific accumulation and therapeutic effect of the histone variant H2A. Z in Alzheimer’s disease. Alzheimer's & Dementia. 2023.  More

2022

Orouji E, Raman AT. Computational methods to explore chromatin state dynamics. Briefings in Bioinformatics. 2022.  More

Boutzen H, ...  Orouji E, ... , Dick JE.  A primary patient-derived model for investigating functional heterogeneity within the human Leukemic Stem Cell Compartment. Leukemia. 2022.  More

Nachmias B, ...  Orouji E, ... , Schimmer AD.  IPO11 Regulates the Nuclear Import of BZW1/2 and Is Necessary for AML Cells and Stem Cells. Leukemia. 2022.  More

Orouji E, Raman AT, ... , Rai K. Chromatin state dynamics confers specific therapeutic strategies in enhancer subtypes of colorectal cancer. Gut. 2022.  More

Boutzen H, ...  Orouji E, ... , Dick JE.  A primary patient-derived model for investigating functional heterogeneity within the human Leukemic Stem Cell Compartment. BioRxiv. 2022.  More

2021 

Terranova C, Tang M, ... , Orouji E, ... , Rai K. Reprogramming of bivalent chromatin states in NRAS mutant melanoma suggests PRC2 inhibition as a therapeutic strategy. Cell Reports. 2021. More

Thomas GE, ... , Orouji E, ... Schimmer AD. The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal hematopoietic stem/progenitor cells to maintain stemness. Cancer Research. 2021. More

Liu Y, Baggerly KA, Orouji E, ... , Morris JS. Methylation-eQTL Analysis in Cancer Research. Bioinformatics. 2021. More

Terranova C, Maitituoheti M, ... , Orouji E, ... , Rai K. H3K4me1-marked Enhancer Activation in Resistant Prostate Cancers Implicates SOX4 and MENIN Inhibition as Therapeutic Strategies. BioRxiv. 2021. More

2020

Maitituoheti M, Keung EZ, ... , Orouji E, Rai K. Enhancer Reprogramming Confers Dependence on Glycolysis and IGF Signaling in KMT2D Mutant Melanoma. Cell Reports. 2020.

Singh RP, ... , Orouji E, Aaron Schimmer. Disrupting Mitochondrial Copper Distribution Inhibits Leukemic Stem Cell Self-Renewal. Cell Stem Cell, 2020

Orouji E, Peitsch WK, Orouji A, Houben R, Utikal J. Oncogenic role of an epigenetic reader of m6A RNA modification, YTHDF1 in Merkel cell carcinoma. Cancers. 2020. 

Orouji E, Peitsch WK, Orouji A, Houben R, Utikal J. Unique Role of Histone Methyltransferase PRDM8 in the Tumorigenesis of Virus-Negative Merkel Cell Carcinoma. Cancers. 2020. 

2019

Orouji E, Federico A, Larribère L, Novak D, Gebhardt C, Umansky V, Utikal J. The histone methyltransferase SETDB1 contributes to melanoma tumorigenesis and represents a new potential therapeutic melanoma target. Int J Cancer. 2019.

Terranova C, Tang M, ... , Orouji E, Rai K.  Bivalent and Broad Chromatin Domains Regulate Pro-metastatic Drivers in Melanoma. BioRxiv. 2019.