Epigenome Lab
PRINCESS MARGARET CANCER CENTRE - TORONTO
Elias Orouji, MD, PhD
Epigenome Lab at Princess Margaret Genomics Centre
Our research delves into the epigenomic landscape of human cells as they undergo the critical transformation from pre-cancerous states to full-blown tumors. By dissecting the intricate transitions in chromatin states during cancer progression, we leverage advanced computational approaches to uncover the underlying mechanisms. These insights are paving the way for the development of targeted therapies that can precisely disrupt these chromatin alterations, offering new hope in the fight against cancer.
Epigenomics | Chromatin states | 3D genome architecture | Cancer epigenetics | Targeted therapies
Epigenome-based Classification (EpiC) leverages patterns of histone modifications to stratify CRC tumors with higher precision, capturing additional tumor heterogeneity not visible through genomic or transcriptomic data alone. This integration of epigenomic data could complement existing classifications (e.g. CMS, CRIS, PDS) by identifying new therapeutic targets and providing insights into the tumor's regulatory landscape, thereby supporting the development of more tailored and effective therapeutic strategies.
Chromatic State Dynamics in CRC
CRC Epigenomic Subtypes
'EpiC' Therapeutic Approach
